The objectives of this project are to study the epidemiology of human neoplasms, and develop etiologic hypotheses through close observation of individual patients at the bedside. There have been several questionnaires developed to help gather new data on genetic and laboratory investigation. Familial aggregates of specific cancers have been identified for further epidemiologic and laboratory investigation. A Registry of Survivors of Childhood Cancer has been established to study carcinogenesis and other sequelae of cancer. Studies at the Field Station generate etiologic hypotheses for clinical and laboratory testing. The studies help to evaluate the relevance for human populations of etiologic data provided by others at the Institute.